Graduate School of Information Science and Technology,
Osaka University
Shimizu Lab.
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Graduate School of Information Science and Technology,
Osaka University
Shimizu Lab.

Member

Teppei Niide

プロフィール

大阪大学大学院情報科学研究科代謝情報工学研究室助教



研究テーマ

・タンパク質工学

・代謝工学


代謝経路の拡張や制御を志向し、機械学習やタンパク質モデリングソフトを活用したタンパク質工学に取り組んでいます。


経歴

2014年3月　九州大学大学院工学府化学システム工学専攻　博士課程修了

2014年4月　東北大学大学院工学研究科バイオ工学専攻　博士研究員

2017年4月　東北大学大学院工学研究科バイオ工学専攻　助教

2019年3月–2020年3月　ノースカロライナ大学チャペルヒル校　客員研究員

2020年4月　大阪大学大学院情報科学研究科バイオ情報工学専攻　助教


原著論文

  1. C. Matsuyama, T. Seike, N. Okahashi, T. Niide, K. Y. Hara, J. Ishii, H. Shimizu, Y. Toya, F. Matsuda “Metabolome analysis of metabolic burden in Escherichia coli caused by overexpression of green fluorescent protein and delta-rhodopsin” J. Biosci. Bioeng., 137(3), 187–194 (2024)
  2. K. Miyoshi, R. Kawai, T. Niide, Y. Toya, H. Shimizu “Functional evaluation of non-oxidative glycolysis in Escherichia coli in the stationary phase under microaerobic conditions” J. Biosci. Bioeng., 135(4), 291–297 (2023)
  3. S. Sugiki, T. Niide, Y. Toya, H. Shimizu “Logistic Regression-guided Identification of Cofactor Specificity-contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties” ACS Synth. Biol., 11(12), 3973–3985 (2022)
  4. R. Kawai, Y. Toya, K. Miyoshi, M. Murakami, T. Niide, T. Horinouchi, T. Maeda, A. Shibai, C. Furusawa, H. Shimizu “Acceleration of target production in co-culture by enhancing intermediate consumption through adaptive laboratory evolution” Biotechnol. Bioeng., 119 (3), 936–945 (2022)
  5. H. Nakazawa, T. Onodera-Sugano, A. Sugiyama, Y. Tanaka, T. Hattori, T. Niide, H. Ogata, R. Asano, I. Kumagai, M. Umetsu “Association behavior and control of the quality of cancer therapeutic bispecific diabodies expressed in Escherichia coli” Biochem. Eng. J., 160 (15), 107636. (2020)
  6. V. Holišová, Z. Konvičcková, G. Kratošová, M. Kolenčcík, T. Niide, M. Umetsu, D. Plachá “Phytosynthesis of Au and Au/ZrO 2 bi-Phasic System Nanoparticles with Evaluation of Their Colloidal Stability” J. Nanosci. Nanotechnol., 19 (5), 2807–2813 (2019)
  7. T. Niide, N. Manabe, H. Nakazawa, K. Akagi, T. Hattori, I. Kumagai, M. Umetsu “Complementary design for pairting between two types of nanoparticles mediated by a bispecific antibody: bottom-up formation of porous materials from nanoparticles” Langmuir, 35 (8), 3067–3076 (2019)
  8. Y. Saito, M. Oikawa, H. Nakazawa, T. Niide, T. Kameda, K. Tsuda, M. Umetsu “Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins” ACS Synth. Biol., 7 (9), 2014–2022 (2018)
  9. H. Fujii, Y. Tanaka, H. Nakazawa, A. Sugiyama, N. Manabe, A. Shinoda, N. Shimizu, T. Hattori, K. Hosokawa, T. Sujino, T. Ito, T. Niide, R. Asano, I. Kumagai, M. Umetsu “Compact Seahorse-Shaped T Cell–Activating Antibody for Cancer Therapy” Adv. Therap. 1, 1700031 (2018)
  10. Z. Konvičková, V. Holišová, M. Kolenčík, T. Niide, G. Kratošová, M. Umetsu J. Seidlerová “Phytosynthesis of colloidal Ag-AgCl nanoparticles mediated by Tilia sp. leachate, evaluation of their behaviour in liquid phase and catalytic properties” Colloid Polym. Sci., 296, 677–687 (2018)
  11. A. Sugiyama, M. Umetsu, H. Nakazawa, T. Niide, R. Asano, T. Hattori, I. Kumagai “High-throughput cytotoxicity and antigen-binding assay for screening small bispecific antibodies without purification” J. Biosci. Bioeng., 17, 31237-31239 (2018)
  12. A. Sugiyama, M. Umetsu, H. Nakazawa, T. Niide, T. Onodera, K. Hosokawa, S. Hattori, R. Asano, I. Kumagai “A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity” Sci. Rep., 7, 2862, 1–12 (2017)
  13. Y. Hosomomi, T. Niide, R. Wakabayashi, M. Goto, N. Kamiya “Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells” Anal. Sci., 32, 295–300 (2016)
  14. T. Niide, K. Ozawa, H. Nakazawa, D. Oliveira, H. Kasai, M. Onodera, R. Asano, I. Kumagai, M. Umetsu “Organic crystal-binding peptide: Morphology control and one-pot formation of protein-displaying organic crystals” Nanoscale, 7, 20155–20163 (2015)
  15. T. Niide, M. Goto, N. Kamiya “Enzymatic self-sacrificial display of an active protein on gold nanoparticles” RSC Adv., 4, 5995–5998 (2014)
  16. T. Niide, K. Shimojo, R. Wakabayashi, M. Goto, N. Kamiya “Enzymatic fabrication of protein-decorated gold nanoparticles by the aid of artificial peptides with gold-binding affinity”, Langmuir, 29, 15596–15605 (2013)
  17. K. Shimojo, T. Niide, T. Taguchi, H. Naganawa, N. Kamiya, M. Goto “Facile, rapid and efficient biofabrication of gold nanoparticles decorated with functional proteins”, Analyst, 137, 2300–2303 (2012)
  18. T. Niide, M. Goto, N. Kamiya “Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells”, Chem. Chommun., 47, 7350–7352 (2011)
  19. T. Oshima, T. Niide, H. Shiraki, Y. Baba, “Preparation and separation of heme iron preparation from fish blood of cultured yellowtail”, Kagaku Kogaku Ronbunshu, 37, 51–56 (2011)
  20. Y. Shimada, T. Niide, F. Kubota, N. Kamiya, M. Goto, “Selective separation of precious metals using biomass materials”, Kagaku Kogaku Ronbunshu, 36, 255–258 (2010)
  21. T. Niide, H. Shiraki, T. Oshima, Y. Baba, N. Kamiya, M. Goto, “Quaternary ammonium bacterial cellulose for adsorption of proteins”, Solvent Extr. Res. Dev., 17, 73- 81 (2010)


解説

  1. 梅津光央, 中澤光, 二井手哲平 ”材料表面を認識するペプチド・タンパク質から発想するハイブリッドナノアッセンブリ”  月刊 BIOINDUSTRY 39(3) 27 2022年3月
  2. 二井手哲平 ”タンパク質の構造予測と設計に関する動向”  化学工学会誌 86(2) 90 2022年2月
  3. 二井手哲平 ”古代生物が持っていたタンパク質を復元する” 生物工学会誌 100(1) 46 2022年1月  
  4. 二井手哲平, 中澤光, 梅津光央 “親水性ペプチド分子による有機結晶の構造制御と生体分子-半導体有機結晶ハイブリッド材料作製プロセスの開発” ケミカルエンジニヤリング 62(7), 23-27, 2017年7月
  5. 梅津光央, 中澤光, 二井手哲平 “構造情報を取り入れた進化工学アプローチによる分子認識タンパク質の設計” MEDCHEM NEWS, 27(1), 25-29, 2017年2月